- Review Article
- General Pediatrics
- Quality improvement in pediatric care
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Moon Sung Park
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Clin Exp Pediatr. 2018;61(1):1-5. Published online January 22, 2018
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We often overlook the importance of several safety issues such as identification of patients, timeout procedure, hand hygiene, handoff communication, and many others. This ignorance, along with many other issues, leads to medical error being ranked as a third leading cause of death in the U.S. Consequently, quality improvement (QI) has become one of the major subjects in healthcare despite... |
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- Case Report
- Neonatology (Perinatology)
- Successfully treated infective endocarditis caused by methicillin-resistant Staphylococcus Aureus in extremely low birth weight infant
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Sehwa Jung, Kyung Uk Jeong, Jang Hoon Lee, Jo Won Jung, Moon Sung Park
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Clin Exp Pediatr. 2016;59(2):96-99. Published online February 29, 2016
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Survival rates of preterm infants have improved in the past few decades, and central venous catheters play an important role in the intensive medical treatment of these neonates. Unfortunately, these indwelling catheters increase the risk of intracardiac thrombosis, and they provide a nidus for microorganisms during the course of septicemia. Herein, we report a case of persistent bacteremia due to... |
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- Original Article
- The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia
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Sang Bum Kim, Jang Hoon Lee, Juyoung Lee, Seung Han Shin, Ho Sun Eun, Soon Min Lee, Jin A Sohn, Han Suk Kim, Byung Min Choi, Min Soo Park, Kook In Park, Ran Namgung, Moon Sung Park
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Clin Exp Pediatr. 2015;58(9):347-353. Published online September 21, 2015
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Purpose The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). MethodsThe Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA).... |
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- The control of invasive Candida infection in very low birth weight infants by reduction in the use of 3rd generation cephalosporin
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Yu Jin Chang, Il Rak Choi, Won Sub Shin, Jang Hoon Lee, Yun Kyung Kim, Moon Sung Park
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Clin Exp Pediatr. 2013;56(2):68-74. Published online February 25, 2013
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Purpose To evaluate the effectiveness of new management policies on the incidence of invasive Candida infections MethodsThis observational study involved a retrospective analysis of the patients' medical records. In total, 99 very low birth weight infants, who were admitted to the neonatal intensive care unit at Ajou University Hospital from January 2010 to December 2011, were enrolled for the study. Period I,... |
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- Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage
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Il Rak Choi, Jang Hoon Lee, Moon Sung Park, Ji Yeon Kim, Kyu Hee Park, Gun-Ha Kim, So-Hee Eun
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Clin Exp Pediatr. 2012;55(11):414-419. Published online November 23, 2012
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Purpose This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome. MethodsBayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (≤grade II) or... |
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- Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
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Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
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Clin Exp Pediatr. 2004;47(2):193-203. Published online February 15, 2004
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Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated.
Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and... |
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- Medical Lecture Course
- Clara Cell Secretory Protein
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Moon Sung Park
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Clin Exp Pediatr. 2002;45(12):1477-1483. Published online December 15, 2002
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- Original Article
- Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
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Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
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Clin Exp Pediatr. 1999;42(4):472-483. Published online April 15, 1999
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Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS.
Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of... |
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- Case Report
- Meckel-Gruber syndrome
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Jung Seo Park, Ji Yoen Lee, Sun Chan Bae, Moon Sung Park, Jung Seon Kim, Si Houn Hahn, Chang Ho Hong
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Clin Exp Pediatr. 1998;41(6):856-860. Published online June 15, 1998
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Meckel-Gruber syndrome is a multiple malformation syndrome featuring occipital meningoencephalocele, multicystic dysplasia of kidney, cystic and fibrotic change of liver, polydactyly, and other characteristics inherited by the autosomal recessive trait. We exprienced a case of Meckel-Gruber syndrome in a newborn male diagnosed clinically and confirmed pathologically. Abnormalities of the fetus were found prenataly by ultrasonogram, and subsequently the baby was... |
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- A Case of FGFR2 Exon Ⅲc Mutation in Crouzon Syndrome
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Seon Chan Bae, Eun Ha Lee, Moon Sung Park, Si Houn Hah, Chang Ho Hong
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Clin Exp Pediatr. 1998;41(12):1717-1721. Published online December 15, 1998
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Crouzon syndrome, an autosomal dominant disorder, has characteristic features of craniosynostosis, hypertelorism, exophthalmos, maxillary hypoplasia and relative mandibular prognathism. Mutations of fibroblast growth factor receptor 2(FGFR2) gene are associated with craniosynostotic conditions, such as Crouzon syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome, Apert syndrome and Beare-Stevenson cutis gyrata. We found one child with common morphological features of Crouzon syndrome. Interestingly, she... |
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- Original Article
- Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
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Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
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Clin Exp Pediatr. 1997;40(6):771-785. Published online June 15, 1997
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Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in
premature babies. For the treatment of RDS at present surfactants such as Surfacten․
(Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant
from the Ministry of Science and Technology for a model research project of Medium-Technology
program, we have modified (supplemented) the bovine lung... |
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- Case Report
- A Case of Tethered Cord Syndrome
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Sook Yeong Jeon, Ki Hyoung Lee, Moon Sung Park, Ok Wha Kim
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Clin Exp Pediatr. 1996;39(11):1636-1640. Published online November 15, 1996
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Tethered cord syndrome is one of the spinal dysraphism with low-lying conus medullaris
frequently associated with spinal lipoma, diastematomyelia and thick filum. The clinical
manifestation is variable from no overt symptoms for a long time to back pain, scoliosis,
progressive neurological deficit of legs and incontinence. Therefore the diagnosis requires a
strong clinical suspicion and aggressive investigation.
We experienced a case of 1 day-old male... |
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- Original Article
- The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
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Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
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Clin Exp Pediatr. 1995;38(5):602-611. Published online May 15, 1995
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Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis.
Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine... |
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- Neonatal Neurosonographic Findings, Cerebral Doppler and Electrophysiological Findings in Infants with Motor Idsturbance
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Jae Kwang Kim, Kook In Park, Chang Il Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
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Clin Exp Pediatr. 1995;38(4):445-460. Published online April 15, 1995
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Purpose : Neurosonography, cerebral doppler and electrophysiological study are valuable in predicting neurodevelopmental outcome. The purpose of this study was to analyze characteristics of neonatal neurosonographic findigs, cerebral doppler and electrophysiological findings in infants withmotor disturbance.
Methods : The subjects were 33 infants hospitalized at Yonsei Severance Medical Center NICU from January, 1990 to December, 1992. 19 of these patients underwent... |
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- Case Report
- A Case of Hemimegalencephaly with Intraventricular Hemorrhage and Multifocal Intraparenchymal Hemorrage on Deep White Matter of Periventricular Area
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Jin Sung Ko, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwang Han, Choon Sik Yoon
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Clin Exp Pediatr. 1995;38(4):561-566. Published online April 15, 1995
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Hemimegalencephaly is a rare congenital anomaly characterized by a intractable seizure an infantile death. This disease is a migrational disorder with enlargement of unilateral hemisphere, abnormal gyration of the cortex, the presence of large and atypical neuron, hetero trophic neuron at subcortical area and proliferation of astrocyte ect.
We observed a neonate with neonatal seizure, and the radiological evaluation revealed abnormal... |
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- Original Article
- Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
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Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
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Clin Exp Pediatr. 1994;37(8):1035-1047. Published online August 15, 1994
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Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX.
Methods : Hypoxic-ischemic brain injury in 7-day-old rats was... |
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- Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
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Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
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Clin Exp Pediatr. 1994;37(4):457-463. Published online April 15, 1994
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Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and... |
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- Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
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Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
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Clin Exp Pediatr. 1994;37(10):1357-1363. Published online October 15, 1994
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In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University... |
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